Atypical antipsychotic drugs, by definition, differ from typical antipsychotic agents in
producing significantly fewer extrapyramidal symptoms and having a lower risk of tardive …

The data surveyed in this book suggest that psychiatric drug treatment is currently
administered on the basis of ahuge collective myth; the myth that psychiatric drugs act by …

The purpose of this article is to discuss the prediction of cognitive enhancement in
schizophrenia from preclinical data. Despite increasing focus on the significance of cognitive …

Rationale Olanzapine is a neuroleptic drug widely prescribed to treat schizophrenia and
bipolar disorder. Although it is long known that modulation of the dopamine system is a …

Rationale Kratom is proposed to exhibit therapeutic potential as an opium substitute, but
little is known about its dependence-producing profile, particularly of its main psychoactive …

The rate of comorbid substance use disorder in patients with schizophrenia is 3 times higher
than that in the general population. Men with schizophrenia appear to be particularly …

Antipsychotic sensitization and tolerance refer to the increased and decreased drug effects
due to past drug use, respectively. Both effects reflect the long-term impacts of antipsychotic …

Rationale Atypical antipsychotic-induced weight gain is a significant impediment in the
treatment of schizophrenia. Objectives In a putative model of antipsychotic drug-induced …

Phthalate administration to male rats has been shown to negatively impact neural
development while development of the female rat brain is less affected. Because a number …

Up to 50% of individuals with intellectual and developmental disabilities (IDD) engage in
problem behavior (PB). These behaviors often interfere with skills acquisition and service …