Role of physiology, immunity, microbiota, and infectious diseases in the gut health of poultry

SS Wickramasuriya, I Park, K Lee, Y Lee, WH Kim… - Vaccines, 2022 - mdpi.com
“Gut health” refers to the physical state and physiological function of the gastrointestinal tract
and in the livestock system; this topic is often focused on the complex interacting …

Coccidiosis: recent progress in host immunity and alternatives to antibiotic strategies

Y Lee, M Lu, HS Lillehoj - Vaccines, 2022 - mdpi.com
Coccidiosis is an avian intestinal disease caused by several distinct species of Eimeria
parasites that damage the host's intestinal system, resulting in poor nutrition absorption …

[HTML][HTML] Efficacy of Bacillus subtilis to replace in-feed antibiotics of broiler chickens under necrotic enteritis-challenged experiments: a systematic review and meta …

N Ningsih, AN Respati, D Astuti, T Triswanto… - Poultry Science, 2023 - Elsevier
Necrotic enteritis (NE) and coccidiosis are among the most prevalent infectious diseases in
broiler chickens, contributing to large profitability losses. Bacillus subtilis is a promising …

Role of Clostridium perfringens Necrotic Enteritis B-like Toxin in Disease Pathogenesis

KW Lee, HS Lillehoj - Vaccines, 2021 - mdpi.com
Necrotic enteritis (NE) is a devastating enteric disease caused by Clostridium perfringens
type A/G that impacts the global poultry industry by compromising the performance, health …

Protective efficacy of multiepitope vaccines constructed from common antigens of Eimeria species in chickens

C Chen, J Su, M Lu, L Xu, R Yan, X Li, X Song - Veterinary Research, 2023 - Springer
Clinical avian coccidiosis is typically caused by coinfection with several Eimeria species.
Recombinant protein and DNA vaccines have shown promise in controlling coccidiosis. On …

Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected …

SS Wickramasuriya, I Park, Y Lee, LM Richer… - Poultry Science, 2023 - Elsevier
We recently reported a stable Bacillus subtilis-carrying chicken NK-lysin peptide (B. subtilis-
cNK-2) as an effective oral delivery system of an antimicrobial peptide to the gut with …

Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1α vaccination against Eimeria maxima infection in broiler …

Y Lee, I Park, SS Wickramasuriya, JB Arous, ME Koziol… - Poultry Science, 2022 - Elsevier
This study was conducted to develop a recombinant Eimeria elongation factor-1α (EF-1α)-
vaccination strategy against Eimeria maxima (E. maxima) infection by co-administering with …

Host-mediated beneficial effects of phytochemicals for prevention of avian coccidiosis

I Park, H Nam, SS Wickramasuriya, Y Lee… - Frontiers in …, 2023 - frontiersin.org
Both in vitro and in vivo studies were conducted to evaluate the beneficial effects of green
tea extract (GT), cinnamon oil (CO), and pomegranate extract (PO) on avian coccidiosis. In …

Oral administration of chicken NK-lysin or recombinant chicken IL-7 improves vaccine efficacy of Eimeria tenella elongation factor-1α (EF-1α) against coccidiosis in …

Y Lee, I Park, HS Lillehoj - Poultry Science, 2023 - Elsevier
The synergistic effects of orally-delivered chicken NK-lysin peptide 2 (cNK-2) or recombinant
chicken IL-7 (rchIL-7) on vaccination with recombinant Eimeria elongation factor-1α (rEF-1α) …

Development of a new immunodiagnostic tool for poultry coccidiosis using an antigen-capture sandwich assay based on monoclonal antibodies detecting an …

Y Lee, HS Lillehoj - Poultry Science, 2023 - Elsevier
This study was conducted to develop an antigen-capture ELISA that detects an
immunodominant antigen of Eimeria, 3-1E which is present in all Eimeria species, using a …