The currently available arsenal of anticancer modalities includes many DNA damaging
agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both …

Although the heat-stress response has been extensively studied for decades, very little is
known about its effects on nucleic acids and nucleic acid-associated processes. This is due …

It has long been established that hyperthermia increases the therapeutic benefit of radiation
and chemotherapy in cancer treatment. During the last few years there have been …

Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular
response to HS utilizes ancient molecular networks that are based primarily on the action of …

Recent studies have suggested that visualization of γ-H2AX nuclear foci can be used to
estimate exposure to very low doses of ionizing radiation. Although this approach is widely …

Human cells accumulate at least 10,000 DNA lesions every day. Failure to repair such
lesions can lead to mutations, genomic instability, or cell death. Among the various types of …

Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat
induction and represents a concept that is far from new as it goes back to ancient times …

Heat stress is one of the best-studied cellular stress factors; however, little is known about its
delayed effects. Here, we demonstrate that heat stress induces p21-dependent cellular …

Heat shock (HS) is one of the better-studied exogenous stress factors. However, little is
known about its effects on DNA integrity and the DNA replication process. In this study, we …

DNA double-strand breaks (DSBs) are a highly toxic form of DNA damage produced by a
number of carcinogens, drugs, and metabolic abnormalities. Involvement of DSBs in many …