Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

X Hu, Z Xia, K Cai - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Mesenchymal stem cells (MSCs) have been increasingly recognized as a resource for
disease treatment and regenerative medicine. Meanwhile, the unique chemical and physical …

[HTML][HTML] Age-related changes in the inflammatory status of human mesenchymal stem cells: implications for cell therapy

Y Zhang, M Ravikumar, L Ling, V Nurcombe, SM Cool - Stem cell reports, 2021 - cell.com
Human mesenchymal stem/stromal cell (hMSC)-based cell therapies are promising for
treating a variety of diseases. The unique immunomodulatory properties of hMSCs have …

The metabolic changes between monolayer (2D) and three-dimensional (3D) culture conditions in human mesenchymal stem/stromal cells derived from adipose …

P Rybkowska, K Radoszkiewicz, M Kawalec… - Cells, 2023 - mdpi.com
Introduction: One of the key factors that may influence the therapeutic potential of
mesenchymal stem/stromal cells (MSCs) is their metabolism. The switch between …

[HTML][HTML] Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel

Q Zhang, Y Liu, J Li, J Wang, C Liu - Bioactive Materials, 2023 - Elsevier
Exposure to a growth factor abundant milieu has remarkable regenerative and rejuvenating
effects on organ diseases, tissue damage, and regeneration, including skeletal system …

Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization

Y Li, J Zhang, C Wang, Z Jiang, K Lai, Y Wang, G Yang - Acta Biomaterialia, 2023 - Elsevier
The application of mesenchymal stem cell (MSC)-based therapy is expected to make a
significant contribution to the improvement of epithelial sealing around implants. However …

[HTML][HTML] Mesenchymal stromal/stem cells spheroid culture effect on the therapeutic efficacy of these cells and their exosomes: A new strategy to overcome cell therapy …

A Hazrati, K Malekpour, S Soudi… - Biomedicine & …, 2022 - Elsevier
Cell therapy is one of the new treatment methods in which mesenchymal stem/stromal cell
(MSCs) transplantation is one of the cells widely used in this field. The results of MSCs …

Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed …

Y Zhang, J Chen, H Fu, S Kuang, F He… - International journal of …, 2021 - nature.com
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …

[HTML][HTML] Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing

VL Thai, DH Ramos-Rodriguez, M Mesfin, JK Leach - Materials Today Bio, 2023 - Elsevier
Chronic nonhealing wounds are debilitating and diminish one's quality of life, necessitating
the development of improved strategies for effective treatment. Biomaterial-and cell-based …

Biofabrication of composite tendon constructs with the fibrous arrangement, high cell density, and enhanced cell alignment

M Li, Y Wu, T Yuan, H Su, M Qin… - ACS Applied Materials & …, 2023 - ACS Publications
Current tissue-engineered tendons are mostly limited to the replication of fibrous
organizations of native tendons, which lack the biomimicry of a densely packed cell …