Iron Acquisition in Mycobacterium tuberculosis
The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
[HTML][HTML] FeGenie: a comprehensive tool for the identification of iron genes and iron gene neighborhoods in genome and metagenome assemblies
Iron is a micronutrient for nearly all life on Earth. It can be used as an electron donor and
electron acceptor by iron-oxidizing and iron-reducing microorganisms and is used in a …
electron acceptor by iron-oxidizing and iron-reducing microorganisms and is used in a …
From host heme to iron: the expanding spectrum of heme degrading enzymes used by pathogenic bacteria
KV Lyles, Z Eichenbaum - Frontiers in cellular and infection …, 2018 - frontiersin.org
Iron is an essential nutrient for many bacteria. Since the metal is highly sequestered in host
tissues, bound predominantly to heme, pathogenic bacteria often take advantage of heme …
tissues, bound predominantly to heme, pathogenic bacteria often take advantage of heme …
Metabolomic analysis of Mycobacterium tuberculosis reveals metabolic profiles for identification of drug-resistant tuberculosis
P Chaiyachat, B Kaewseekhao, A Chaiprasert… - Scientific Reports, 2023 - nature.com
The detection of pre-extensively (pre-XDR) and extensively drug-resistant tuberculosis (XDR-
TB) is challenging. Drug-susceptibility tests for some anti-TB drugs, especially ethambutol …
TB) is challenging. Drug-susceptibility tests for some anti-TB drugs, especially ethambutol …
Sequence–structure–function classification of a catalytically diverse oxidoreductase superfamily in Mycobacteria
The deazaflavin cofactor F 420 enhances the persistence of mycobacteria during hypoxia,
oxidative stress, and antibiotic treatment. However, the identities and functions of the …
oxidative stress, and antibiotic treatment. However, the identities and functions of the …
Measurement of heme ruffling changes in MhuD using UV–vis spectroscopy
AB Graves, MT Graves, MD Liptak - The Journal of Physical …, 2016 - ACS Publications
For decades it has been known that an out-of-plane ruffling distortion of heme perturbs its
UV–vis absorption (Abs) spectrum, but whether increased ruffling induces a red or blue shift …
UV–vis absorption (Abs) spectrum, but whether increased ruffling induces a red or blue shift …
Unique coupling of mono-and dioxygenase chemistries in a single active site promotes heme degradation
T Matsui, S Nambu, CW Goulding… - Proceedings of the …, 2016 - National Acad Sciences
Bacterial pathogens must acquire host iron for survival and colonization. Because free iron
is restricted in the host, numerous pathogens have evolved to overcome this limitation by …
is restricted in the host, numerous pathogens have evolved to overcome this limitation by …
Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme
PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20
protein families sharing a common α, β-barrel domain. Of these, six different groups bind …
protein families sharing a common α, β-barrel domain. Of these, six different groups bind …
MhuD from Mycobacterium tuberculosis: Probing a Dual Role in Heme Storage and Degradation
SJ Matthews, KJ Pacholarz, AP France… - ACS infectious …, 2019 - ACS Publications
The Mycobacterium tuberculosis (Mtb) heme oxygenase MhuD liberates free iron by
degrading heme to the linear tetrapyrrole mycobilin. The MhuD dimer binds up to two hemes …
degrading heme to the linear tetrapyrrole mycobilin. The MhuD dimer binds up to two hemes …