Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …

Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment
has gained increasing interest. Especially the enhanced selective killing of tumor cells …

Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

S-glutathionylation, the post-translational modification forming mixed disulfides between
protein reactive thiols and glutathione, regulates redox-based signaling events in the cell …

Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular
metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) …

Mitochondria have many forms and can change their shape through fusion and fission of the
outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer …

Anti‐angiogenic medicines have been evaluated as anticancer therapies, however, their
use remains limited in clinical practice due to associated adverse effects. Asiatic acid (AA) is …

Nitric oxide (NO) is a ubiquitous, endogenously produced, water-soluble signaling molecule
playing critical roles in physiological processes. Nitric oxide plays pleiotropic roles in cancer …

Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …

Metabolic plasticity, which determines tumour growth and metastasis, is now understood to
be a flexible and context-specific process in cancer metabolism. One of the major pathways …