HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …

The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …

Abstract Human Immunodeficiency Virus (HIV) relies on host molecular machinery for
replication. Systematic attempts to genetically or biochemically define these host factors …

Viruses of wild and domestic animals can infect humans in a process called zoonosis, and
these events can give rise to explosive epidemics such as those caused by the HIV and …

Detecting a new human virus in the earliest days of a disease outbreak means that
interventions can be implemented while the problem is still small. This at least offers a …

Dominant missense mutations in RanBP2/Nup358 cause Acute Necrotizing Encephalopathy
(ANE), a pediatric disease where seemingly healthy individuals develop a cytokine storm …

Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to
enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine …

The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has
complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for …

Illuminating the role of specific gene duplications within the human lineage can provide
insights into human-specific adaptations. The so-called human core duplicon gene families …

The emergence of a new coronavirus, in around late December 2019 which had first been
reported in Wuhan, China has now developed into a massive threat to global public health …