The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …

The last 50 years have witnessed extraordinary developments in understanding
mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical …

Checkpoint immunotherapy has yielded meaningful responses across many cancers but
has shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7 …

Prostate cancer (PC), the second most prevalent malignancy in men worldwide, has been
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …

Recent evidence highlights patients' sex relevance in antitumor immune response through a
complex interaction—among hormones, genes, behaviors, and the microbiome—that affects …

The safety of municipal sewage sludge has raised great concerns because of the
accumulation of large-scale endocrine disrupting chemicals in the sludge during wastewater …

Background The main objective of this study was to analyze the effects of KRAS/TP53
mutation status and tumor sideness on the immune microenvironment of colorectal cancer …

Sex differences in mammalian complex traits are prevalent and are intimately associated
with androgens,,,,,–. However, a molecular and cellular profile of sex differences and their …

Vitiligo is an autoimmune skin disease caused by cutaneous melanocyte loss. Although
phototherapy and T cell suppression therapy have been widely used to induce epidermal re …