In eukaryotic cells, the endoplasmic reticulum (ER) is constructed as a network of tubules
and sheets that exist in one continuous membrane system. Several classes of integral …

Dynamin superfamily proteins are multidomain mechano‐chemical GTPases which are
implicated in nucleotide‐dependent membrane remodeling events. A prominent feature of …

In higher eukaryotes, the endoplasmic reticulum (ER) contains a network of membrane
tubules, which transitions into sheets during mitosis. Network formation involves curvature …

Mitochondria undergo fusion and fission. The merging of outer mitochondrial membranes
requires mitofusin (MFN), a dynamin-like GTPase. How exactly MFN mediates membrane …

Organelles display characteristic morphologies that are intimately tied to their cellular
function, but how organelles are shaped is poorly understood. The endoplasmic reticulum is …

Fusion of the outer mitochondrial membrane is mediated by the dynamin-like GTPase
mitofusin (MFN). Here, we determined the structure of the minimal GTPase domain (MGD) of …

Lipid droplets (LDs) are critical for lipid storage and energy metabolism. LDs form in the
endoplasmic reticulum (ER). However, the molecular basis for LD biogenesis remains …

Membrane fusion plays a lead role in the transport of vesicles, neurotransmission,
mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and …

Endoplasmic reticulum (ER) membrane junctions are formed by the dynamin-like GTPase
atlastin (ATL). Deletion of ATL results in long unbranched ER tubules in cells, and mutation …

The endoplasmic reticulum (ER) is a major membrane-bound organelle in all eukaryotic
cells. This organelle comprises morphologically distinct domains, including the nuclear …