Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
Axonal degeneration in chemotherapy-induced peripheral neurotoxicity: clinical and experimental evidence
Multiple pathological mechanisms are involved in the development of chemotherapy-
induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the …
induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the …
The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration
Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable
degree of spontaneous anatomical and functional regeneration. To explore extrinsic …
degree of spontaneous anatomical and functional regeneration. To explore extrinsic …
Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
H Zeng, JE Mayberry, D Wadkins, N Chen… - Acta neuropathologica …, 2024 - Springer
Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in
the disease results from the deterioration of retinal ganglion cells (RGC) and their axons …
the disease results from the deterioration of retinal ganglion cells (RGC) and their axons …
Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Introduction The degeneration of injured axons is driven by conserved molecules, including
the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK …
the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK …
Enzymology of Ca2+-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
AH Guse - Cells, 2023 - mdpi.com
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are
precursors for the enzymatic formation of the Ca2+-mobilizing second messengers …
precursors for the enzymatic formation of the Ca2+-mobilizing second messengers …
Abnormal intraepidermal nerve fiber density in disease: A scoping review
Background Intraepidermal nerve fiber density (IENFD) has become an important biomarker
for neuropathy diagnosis and research. The consequences of reduced IENFD can include …
for neuropathy diagnosis and research. The consequences of reduced IENFD can include …
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
Background Bioenergetic maladaptations and axonopathy are often found in the early
stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential …
stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential …
High-Resolution Proteomics Unravel a Native Functional Complex of Cav1. 3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain …
M Belghazi, C Iborra, O Toutendji, M Lasserre… - Cells, 2024 - mdpi.com
Pacemaking activity in substantia nigra dopaminergic neurons is generated by the
coordinated activity of a variety of distinct somatodendritic voltage-and calcium-gated ion …
coordinated activity of a variety of distinct somatodendritic voltage-and calcium-gated ion …
NAD+ metabolism and eye diseases: current status and future directions
S Liu, W Zhang - Molecular Biology Reports, 2023 - Springer
Currently, there are no truly effective treatments for a variety of eye diseases, such as
glaucoma, age-related macular degeneration (AMD), and inherited retinal degenerations …
glaucoma, age-related macular degeneration (AMD), and inherited retinal degenerations …