Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies

PK Kamat, A Kalani, S Rai, S Swarnkar, S Tota… - Molecular …, 2016 - Springer
Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …

[HTML][HTML] Rodent models of neuroinflammation for Alzheimer's disease

A Nazem, R Sankowski, M Bacher… - Journal of …, 2015 - Springer
Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …

[HTML][HTML] Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia

S Kouhestani, A Jafari, P Babaei - Neural Regeneration Research, 2018 - journals.lww.com
Alzheimer's disease (AD) is associated with oxidative stress, and ultimately results in
cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently …

Hydrogen sulfide ameliorates homocysteine-induced Alzheimer's disease-like pathology, blood–brain barrier disruption, and synaptic disorder

PK Kamat, P Kyles, A Kalani, N Tyagi - Molecular Neurobiology, 2016 - Springer
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of
Alzheimer's disease (AD). During transsulfuration pathways, Hcy is metabolized into …

[HTML][HTML] Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism

PK Kamat - Neural regeneration research, 2015 - journals.lww.com
Alzheimer's disease (AD) is a neurodegenerative disorder which is remarkably
characterized by pathological hallmarks that include neurofibrillary tangles, neuronal loss …

[HTML][HTML] A novel NMDA receptor antagonist protects against cognitive decline presented by senescent mice

J Companys-Alemany, AL Turcu, A Bellver-Sanchis… - Pharmaceutics, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-
aspartate (NMDA) receptor antagonist memantine improved cognition and molecular …

Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson's disease

RMC Di Martino, L Pruccoli, A Bisi… - ACS Chemical …, 2020 - ACS Publications
Common copathogenic factors, including oxidative stress and neuroinflammation, are found
to play a vital role in the development of neurodegenerative disorders, including Alzheimer's …

[HTML][HTML] Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents

O Mahdi, MTH Baharuldin, NHM Nor… - Biomedical Research …, 2019 - biomedpress.org
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …

[HTML][HTML] Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease

I Gameiro, P Michalska, G Tenti, Á Cores, I Buendia… - Scientific reports, 2017 - nature.com
The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have
emerged as key targets for the treatment of Alzheimer's disease (AD), the most prevalent …

[PDF][PDF] Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice

AA Hemmati, S Alboghobeish… - The Korean Journal …, 2018 - synapse.koreamed.org
The present study aimed to evaluate the cinnamic acid effect on memory impairment,
oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model …