Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies
Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
[HTML][HTML] Rodent models of neuroinflammation for Alzheimer's disease
A Nazem, R Sankowski, M Bacher… - Journal of …, 2015 - Springer
Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …
[HTML][HTML] Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
Alzheimer's disease (AD) is associated with oxidative stress, and ultimately results in
cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently …
cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently …
Hydrogen sulfide ameliorates homocysteine-induced Alzheimer's disease-like pathology, blood–brain barrier disruption, and synaptic disorder
PK Kamat, P Kyles, A Kalani, N Tyagi - Molecular Neurobiology, 2016 - Springer
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of
Alzheimer's disease (AD). During transsulfuration pathways, Hcy is metabolized into …
Alzheimer's disease (AD). During transsulfuration pathways, Hcy is metabolized into …
[HTML][HTML] Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism
PK Kamat - Neural regeneration research, 2015 - journals.lww.com
Alzheimer's disease (AD) is a neurodegenerative disorder which is remarkably
characterized by pathological hallmarks that include neurofibrillary tangles, neuronal loss …
characterized by pathological hallmarks that include neurofibrillary tangles, neuronal loss …
[HTML][HTML] A novel NMDA receptor antagonist protects against cognitive decline presented by senescent mice
J Companys-Alemany, AL Turcu, A Bellver-Sanchis… - Pharmaceutics, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-
aspartate (NMDA) receptor antagonist memantine improved cognition and molecular …
aspartate (NMDA) receptor antagonist memantine improved cognition and molecular …
Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson's disease
RMC Di Martino, L Pruccoli, A Bisi… - ACS Chemical …, 2020 - ACS Publications
Common copathogenic factors, including oxidative stress and neuroinflammation, are found
to play a vital role in the development of neurodegenerative disorders, including Alzheimer's …
to play a vital role in the development of neurodegenerative disorders, including Alzheimer's …
[HTML][HTML] Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …
characterised by multiple cognitive impairments and personality changes. Different methods …
[HTML][HTML] Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease
I Gameiro, P Michalska, G Tenti, Á Cores, I Buendia… - Scientific reports, 2017 - nature.com
The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have
emerged as key targets for the treatment of Alzheimer's disease (AD), the most prevalent …
emerged as key targets for the treatment of Alzheimer's disease (AD), the most prevalent …
[PDF][PDF] Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice
AA Hemmati, S Alboghobeish… - The Korean Journal …, 2018 - synapse.koreamed.org
The present study aimed to evaluate the cinnamic acid effect on memory impairment,
oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model …
oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model …