Human guanylate binding proteins: nanomachines orchestrating host defense
Disease‐causing microorganisms not only breach anatomical barriers and invade tissues
but also frequently enter host cells, nutrient‐enriched environments amenable to support …
but also frequently enter host cells, nutrient‐enriched environments amenable to support …
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions
Guanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse
biological functions, including pathogen sensing and host defense against infectious …
biological functions, including pathogen sensing and host defense against infectious …
[HTML][HTML] Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Cell-intrinsic defense is an essential part of the immune response against intracellular
pathogens regulated by cytokine-induced proteins and pathways. One of the most …
pathogens regulated by cytokine-induced proteins and pathways. One of the most …
Functional cross-species conservation of guanylate-binding proteins in innate immunity
L Schelle, JV Côrte-Real, PJ Esteves… - Medical Microbiology …, 2023 - Springer
Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely
distributed among eukaryotes. They are interferon (IFN)-inducible guanosine …
distributed among eukaryotes. They are interferon (IFN)-inducible guanosine …
Structural basis of antimicrobial membrane coat assembly by human GBP1
T Kuhm, C Taisne, C de Agrela Pinto, L Gross… - Nature Structural & …, 2024 - nature.com
Guanylate-binding proteins (GBPs) are interferon-inducible guanosine triphosphate
hydrolases (GTPases) mediating host defense against intracellular pathogens. Their …
hydrolases (GTPases) mediating host defense against intracellular pathogens. Their …
Comparative study of GBP recruitment on two cytosol-dwelling pathogens, Francisella novicida and Shigella flexneri highlights differences in GBP repertoire and in …
SV Valeva, M Degabriel, F Michal, G Gay… - Pathogens and …, 2023 - academic.oup.com
Abstract Guanylate-Binding Proteins are interferon-inducible GTPases that play a key role in
cell autonomous responses against intracellular pathogens. Despite sharing high sequence …
cell autonomous responses against intracellular pathogens. Despite sharing high sequence …
Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2
J Loschwitz, N Steffens, X Wang, M Schäffler… - Scientific reports, 2023 - nature.com
Guanylate-binding proteins (GBPs) are a group of GTPases that are induced by interferon-γ
and are crucial components of cell-autonomous immunity against intracellular pathogens …
and are crucial components of cell-autonomous immunity against intracellular pathogens …
Structural insights into the activation mechanism of antimicrobial GBP1
The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …
Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and …
Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are
widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases …
widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases …
[HTML][HTML] The Large GTPase Guanylate-Binding Protein-1 (GBP-1) Promotes Mitochondrial Fission in Glioblastoma
RC Kalb, GO Nyabuto, MP Morran, S Maity… - International Journal of …, 2024 - mdpi.com
Glioblastomas (aka Glioblastoma multiformes (GBMs)) are the most deadly of the adult brain
tumors. Even with aggressive treatment, the prognosis is extremely poor. The large GTPase …
tumors. Even with aggressive treatment, the prognosis is extremely poor. The large GTPase …