Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens
T-cell-mediated immunotherapies are limited by the extent to which cancer-specific antigens
are homogenously expressed throughout a tumor. We reasoned that recurrent splicing …
are homogenously expressed throughout a tumor. We reasoned that recurrent splicing …
[HTML][HTML] A genomic enhancer signature associates with hepatocellular carcinoma prognosis
Abstract Background & Aims Lifestyle and environmental-related exposures are important
risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation …
risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation …
Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence
A Aiderus, PV Seshachalam, K Idzham, M Caldez… - bioRxiv, 2023 - biorxiv.org
Hepatocellular carcinomas (HCC) are driven by various etiologies and molecular diversity at
presentation. Patient prognosis post-surgery is generally dismal, and the majority respond …
presentation. Patient prognosis post-surgery is generally dismal, and the majority respond …
Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens
T-cell-based immunotherapies hold promise in treating cancer by leveraging the immune
system's recognition of cancer-specific antigens. 1 However, their efficacy is often limited in …
system's recognition of cancer-specific antigens. 1 However, their efficacy is often limited in …