K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Redox imbalance and persistent inflammation are the underlying causes of most chronic
diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox …

The Nrf2–Keap1 system plays a major role in cellular defense against oxidative stress. Upon
exposure to electrophiles, the cysteine-rich protein Keap1 is covalently modified, and it is …

Hippocampal sclerosis is a common acquired disease that is a major cause of drug-resistant
epilepsy. A mechanism that has been proposed to lead from brain insult to hippocampal …

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress.
We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the …

Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …

The preparation methods and reactions of isoxazoles are described and systematized on
the basis of analysis of the literature published from 2005 to present. In the discussion of …

Nitrated oleic acid (NO 2-OA) was first identified in 2003, and after the characterization of its
formation and thiol reactivity, it was used as a prototypical molecule to investigate the …

Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-
responsive kinases that modulates cell growth, apoptosis, proliferation and development …