The metabolic cooperation between cells in solid cancer tumors
P Icard, P Kafara, JM Steyaert, L Schwartz… - Biochimica et Biophysica …, 2014 - Elsevier
Cancer cells cooperate with stromal cells and use their environment to promote tumor
growth. Energy production depends on nutrient availability and O 2 concentration. Well …
growth. Energy production depends on nutrient availability and O 2 concentration. Well …
Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer
Metastatic recurrence is the leading cause of cancer-related deaths in patients with
colorectal carcinoma. To capture the molecular underpinnings for metastasis and tumor …
colorectal carcinoma. To capture the molecular underpinnings for metastasis and tumor …
Experimental therapy of advanced breast cancer: targeting NFAT1–MDM2–p53 pathway
Advanced breast cancer, especially advanced triple-negative breast cancer, is typically
more aggressive and more difficult to treat than other breast cancer phenotypes. There is …
more aggressive and more difficult to treat than other breast cancer phenotypes. There is …
[HTML][HTML] Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation
A Sorrentino, AN Menevse, T Michels… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Cancer immunotherapeutic strategies showed unprecedented results in the
clinic. However, many patients do not respond to immuno-oncological treatments due to the …
clinic. However, many patients do not respond to immuno-oncological treatments due to the …
The role of NFATc1/c-myc/PKM2/IL-10 axis in activating cervical cancer tumor-associated M2 macrophage polarization to promote cervical cancer progression
J Tan, L Yang, H Zhao, Y Ai, L Ren, F Zhang… - Experimental Cell …, 2022 - Elsevier
Nuclear factor of activated T cells 1 (NFATc1) is mainly expressed in tumor
microenvironment, especially in macrophages. However, whether NFATc1 is involved in the …
microenvironment, especially in macrophages. However, whether NFATc1 is involved in the …
NFATC1 promotes cell growth and tumorigenesis in ovarian cancer up-regulating c-Myc through ERK1/2/p38 MAPK signal pathway
W Xu, J Gu, Q Ren, Y Shi, Q Xia, J Wang, S Wang… - Tumor Biology, 2016 - Springer
It has been reported that nuclear factor of activated T cells (NFATC1) was up-regulated in
cancers mediating malignant behaviors. However, the role of NFATC1 in ovarian cancer has …
cancers mediating malignant behaviors. However, the role of NFATC1 in ovarian cancer has …
Identification and validation of an immune signature associated with EMT and metabolic reprogramming for predicting prognosis and drug response in bladder cancer
Z Zhang, Y Yu, P Li, M Wang, W Jiao, Y Liang… - Frontiers in …, 2022 - frontiersin.org
Background Epithelial-mesenchymal transition (EMT), one leading reason of the dismal
prognosis of bladder cancer (BLCA), is closely associated with tumor invasion and …
prognosis of bladder cancer (BLCA), is closely associated with tumor invasion and …
[HTML][HTML] The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
The AKT3 signalling pathway plays a critical role in melanoma formation and invasion and
components of this signalling cascade are therefore attractive targets for the treatment of …
components of this signalling cascade are therefore attractive targets for the treatment of …
High-performance gene expression and knockout tools using sleeping beauty transposon system
Background Similar to retro−/lenti-virus system, DNA transposons are useful tools for stable
expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has …
expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has …
Interleukin (IL)-7 signaling in the tumor microenvironment
I Bednarz-Misa, MA Bromke… - … : The Role of Interleukins …, 2021 - Springer
Abstract Interleukin (IL)-7 plays an important immunoregulatory role in different types of
cells. Therefore, it attracts researcher's attention, but despite the fact, many aspects of its …
cells. Therefore, it attracts researcher's attention, but despite the fact, many aspects of its …