Cancer cells cooperate with stromal cells and use their environment to promote tumor
growth. Energy production depends on nutrient availability and O 2 concentration. Well …

Metastatic recurrence is the leading cause of cancer-related deaths in patients with
colorectal carcinoma. To capture the molecular underpinnings for metastasis and tumor …

Advanced breast cancer, especially advanced triple-negative breast cancer, is typically
more aggressive and more difficult to treat than other breast cancer phenotypes. There is …

Background Cancer immunotherapeutic strategies showed unprecedented results in the
clinic. However, many patients do not respond to immuno-oncological treatments due to the …

Nuclear factor of activated T cells 1 (NFATc1) is mainly expressed in tumor
microenvironment, especially in macrophages. However, whether NFATc1 is involved in the …

It has been reported that nuclear factor of activated T cells (NFATC1) was up-regulated in
cancers mediating malignant behaviors. However, the role of NFATC1 in ovarian cancer has …

Background Epithelial-mesenchymal transition (EMT), one leading reason of the dismal
prognosis of bladder cancer (BLCA), is closely associated with tumor invasion and …

The AKT3 signalling pathway plays a critical role in melanoma formation and invasion and
components of this signalling cascade are therefore attractive targets for the treatment of …

Background Similar to retro−/lenti-virus system, DNA transposons are useful tools for stable
expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has …

Abstract Interleukin (IL)-7 plays an important immunoregulatory role in different types of
cells. Therefore, it attracts researcher's attention, but despite the fact, many aspects of its …