[HTML][HTML] Dynamic regulation of the 26S proteasome: from synthesis to degradation
RS Marshall, RD Vierstra - Frontiers in Molecular Biosciences, 2019 - frontiersin.org
All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …
The proteasome: a suitable antineoplastic target
J Adams - Nature Reviews Cancer, 2004 - nature.com
The proteasome is an abundant multi-enzyme complex that provides the main pathway for
degradation of intracellular proteins in eukaryotic cells. As such, it controls the levels of …
degradation of intracellular proteins in eukaryotic cells. As such, it controls the levels of …
[HTML][HTML] Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
The dipeptide boronic acid bortezomib, also termed VELCADE®, is a proteasome inhibitor
now in use for the treatment of multiple myeloma, and its use for the treatment of other …
now in use for the treatment of multiple myeloma, and its use for the treatment of other …
[HTML][HTML] Proteasome activators
BM Stadtmueller, CP Hill - Molecular cell, 2011 - cell.com
Proteasomes degrade a multitude of protein substrates in the cytosol and nucleus, and
thereby are essential for many aspects of cellular function. Because the proteolytic sites are …
thereby are essential for many aspects of cellular function. Because the proteolytic sites are …
[HTML][HTML] Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
AF Kisselev, A Callard, AL Goldberg - Journal of Biological Chemistry, 2006 - ASBMB
The relative importance of the different proteolytic sites in mammalian proteasomes in
protein degradation has not been studied systematically. Nevertheless, it is widely assumed …
protein degradation has not been studied systematically. Nevertheless, it is widely assumed …
20S proteasome and its inhibitors: crystallographic knowledge for drug development
L Borissenko, M Groll - Chemical reviews, 2007 - ACS Publications
Principles of intracellular protein synthesis and protein degradation remain to be among the
most challenging questions of modern cell biology. Proteolysis plays an important role in …
most challenging questions of modern cell biology. Proteolysis plays an important role in …
[HTML][HTML] Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
Long glutamine sequences (polyQ) occur in many cell proteins, and several
neurodegenerative diseases result from expansion of these sequences. PolyQ-containing …
neurodegenerative diseases result from expansion of these sequences. PolyQ-containing …
Heat shock proteins in neurodegenerative disorders and aging
RK Leak - Journal of cell communication and signaling, 2014 - Springer
Many members of the heat shock protein family act in unison to refold or degrade misfolded
proteins. Some heat shock proteins also directly interfere with apoptosis. These homeostatic …
proteins. Some heat shock proteins also directly interfere with apoptosis. These homeostatic …
A novel membrane fusion-mediated plant immunity against bacterial pathogens
N Hatsugai, S Iwasaki, K Tamura, M Kondo… - Genes & …, 2009 - genesdev.cshlp.org
Plants have developed their own defense strategies because they have no immune cells. A
common plant defense strategy involves programmed cell death (PCD) at the infection site …
common plant defense strategy involves programmed cell death (PCD) at the infection site …
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates
AF Kisselev, AL Goldberg - Methods in enzymology, 2005 - Elsevier
Eukaryotic proteasomes have three different types of active sites: two chymotrypsin‐like, two
trypsin‐like, and two caspase‐like (also termed PGPH) sites that differ in their specificity …
trypsin‐like, and two caspase‐like (also termed PGPH) sites that differ in their specificity …