Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Linking regulatory DNA elements to their target genes, which may be located hundreds of
kilobases away, remains challenging. Here, we introduce Cicero, an algorithm that identifies …

Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells)
that remain quiescent throughout life. Satellite cell regenerative functions decline with …

The niche is a conserved regulator of stem cell quiescence and function. During ageing,
stem cell function declines. To what extent and by what means age-related changes within …

The cell microenvironment, which is critical for stem cell maintenance, contains both cellular
and non-cellular components, including secreted growth factors and the extracellular matrix …

Satellite cells are adult myogenic stem cells that repair damaged muscle. The enduring
capacity for muscle regeneration requires efficient satellite cell expansion after injury, their …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Satellite cells are a heterogeneous population of stem and progenitor cells that are required
for the growth, maintenance and regeneration of skeletal muscle. The transcription factors …

Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as
mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded …