Organization and Evolution of Hox/HOM-C Complexes The genomic structural and
organizational similarities between vertebrate Hox and Drosophila HOM-C complexes …

The connection between development and evolution has become the focus of an increasing
amount of research in recent years, and heterochrony has long been a key concept in this …

Expansions of amino acid repeats occur in> 20 inherited human disorders, and many occur
in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are …

The world's most revered and eloquent interpreter of evolutionary ideas offers here a work of
explanatory force unprecedented in our time—a landmark publication, both for its historical …

Structural genomic variations represent a major driving force of evolution, and a burst of
large segmental gene duplications occurred in the human lineage during its separation from …

Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer 1, but
account for only a small fraction of breast cancer susceptibility 1, 2. To find additional genes …

Morphogenesis depends on the precise control of basic cellular processes such as cell
proliferation and differentiation. Wnt5a may regulate these processes since it is expressed in …

The long bones of the developing skeleton, such as those of the limb, arise from the process
of endochondral ossification, where cartilage serves as the initial anlage element and is …

Vertebrate Hox genes are essential for the proper organiz ation of the body plan during
development. Inactivation of these genes usually leads to important alterations, or …

The morphological and functional evolution of appendages has played a crucial role in the
adaptive radiation of tetrapods, arthropods and winged insects. The origin and …