Direct contact may be an option for supporting disclosure in families with hereditary cancer
risk. In this qualitative interview study, we explored how healthy at-risk relatives experience …

Although multiple factors can influence the uptake of cascade genetic testing, the impact of
proband indication has not been studied. We performed a retrospective, cross-sectional …

Advances in genetic diagnostics lead to more patients being diagnosed with hereditary
conditions. These findings are often relevant to patients' relatives. For example, the success …

Background Targeted surveillance of at-risk individuals in families with increased risk of
hereditary cancer is an effective prevention strategy if relatives are identified, informed and …

The uptake of predictive DNA testing in families with a hereditary disease is< 50%. Current
practice often relies on the proband to inform relatives about the possibility of predictive DNA …

Background The results of germline genetic testing for hereditary cancer are of importance
not only to the patients under investigation but also to their genetic at-risk relatives. Standard …

This study explores perceptions and preferences on receiving genetic risk information about
hereditary cancer risk in members of the Swedish public. We conducted qualitative content …

The increased usage of genetic testing for treatment stratification within the era of precision
medicine entails the potential to detect germline genetic risk variants. Germline genetic …

Objectives The goals of this study were to explore 1) the impact of returning unexpected
pharmacogenomic (PGx) results to biobank contributors, and 2) participant views about …

Cascade genetic testing is essential to clarify cancer risk in families with hereditary breast
and ovarian cancer syndrome (HBOC) due to pathogenic variants (PVs) in BRCA1 or …