Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy

S Dewanjee, J Vallamkondu, RS Kalra, A John… - Ageing research …, 2021 - Elsevier
Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes

SC Kolwicz Jr, S Purohit, R Tian - Circulation research, 2013 - Am Heart Assoc
The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum …

S Wu, Q Lu, Y Ding, Y Wu, Y Qiu, P Wang, X Mao… - Circulation, 2019 - Am Heart Assoc
Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …

SIRT1-FOXOs activity regulates diabetic complications

MP Jalgaonkar, UM Parmar, YA Kulkarni… - Pharmacological …, 2022 - Elsevier
The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection

Y Bei, D Lu, C Bär, S Chatterjee, A Costa, I Riedel… - Molecular Therapy, 2022 - cell.com
Exercise and its regulated molecules have myocardial protective effects against cardiac
ischemia/reperfusion (I/R) injury. The muscle-enriched miR-486 was previously identified to …

Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy

A Wan, B Rodrigues - Cardiovascular research, 2016 - academic.oup.com
The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Melatonin attenuates oxidative stress-induced apoptosis of bovine ovarian granulosa cells by promoting mitophagy via SIRT1/FoxO1 signaling pathway

G Xu, Y Dong, Z Wang, H Ding, J Wang, J Zhao… - International Journal of …, 2023 - mdpi.com
Oxidative-stress-induced apoptosis of granulosa cells is considered to be a main driver of
follicular atresia. Increasing evidence suggests a protective effect of melatonin against …

miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction

A Izarra, I Moscoso, E Levent, S Cañón, I Cerrada… - Stem cell reports, 2014 - cell.com
Summary miR-133a and miR-1 are known as muscle-specific microRNAs that are involved
in cardiac development and pathophysiology. We have shown that both miR-1 and miR …

Effects of short-term endurance exercise training on acute doxorubicin-induced FoxO transcription in cardiac and skeletal muscle

AN Kavazis, AJ Smuder… - Journal of applied …, 2014 - journals.physiology.org
Doxorubicin (DOX) is a potent antitumor agent used in cancer treatment. Unfortunately, DOX
can induce myopathy in both cardiac and skeletal muscle, which limits its clinical use …

Calcineurin signaling in the heart: The importance of time and place

V Parra, BA Rothermel - Journal of molecular and cellular cardiology, 2017 - Elsevier
The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein
phosphorylation and calcium signaling cascades, where it provides an essential nodal point …