Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

The significance of oxidative stress in the development of chronic neurodegenerative
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …

Importance Multiple studies have found an increased prevalence, younger age at onset, and
more severe course of glaucoma in people of African descent, but these findings are based …

The similarities between glaucoma and mitochondrial optic neuropathies have driven a
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …

Alzheimer's disease (AD) is the most common form of dementia. Intraneuronal neurofibrillary
tangles, extracellular Aβ amyloid deposits in the form of amyloid plaques and cerebral …

Background There is accumulating evidence that autoimmune components, such as
autoantibodies and autoantibody depositions, play a role in the pathogenesis of …

Our aim was to assess in primary open angle glaucoma (POAG), a major cause of
irreversible blindness worldwide, whether diffuse brain changes recently shown in …

Normally, trabecular meshwork (TM) and Schlemm's canal inner wall endothelial cells within
the aqueous humor outflow pathway maintain intraocular pressure within a narrow safe …

Optineurin is a gene associated with normal tension glaucoma and primary open‐angle
glaucoma, one of the major causes of irreversible bilateral blindness. Recently, mutations in …

Diseases of the retina are the leading causes of blindness in the industrialized world. The
recognition that animals develop retinal diseases with similar traits to humans has led to not …