Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Steering and controlling evolution—from bioengineering to fighting pathogens
M Lässig, V Mustonen, A Nourmohammad - Nature Reviews Genetics, 2023 - nature.com
Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …
towards a desired outcome. Applications range from engineering biomolecules and …
[HTML][HTML] SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
OV Britanova, KR Lupyr, DB Staroverov, IA Shagina… - Nature Medicine, 2023 - nature.com
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …
Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs
T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen
exposure and potential future response. However, despite advances in deep repertoire …
exposure and potential future response. However, despite advances in deep repertoire …
GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation
Similarity in T-cell receptor (TCR) sequences implies shared antigen specificity between
receptors, and could be used to discover novel therapeutic targets. However, existing …
receptors, and could be used to discover novel therapeutic targets. However, existing …