The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order …

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions,
including transcriptional activation/repression, insulation, imprinting, and X chromosome …

We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and
diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 …

Although population-level analyses revealed significant roles for CTCF and cohesin in
mammalian genome organization, their contributions at the single-cell level remain …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

CTCF (CCCTC-binding factor) binds sites around the mouse β-globin locus that spatially
cluster in the erythroid cell nucleus. We show that both conditional deletion of CTCF and …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Insulators are DNA sequence elements that prevent inappropriate interactions between
adjacent chromatin domains. One type of insulator establishes domains that separate …

The T-helper-cell 1 and 2 (TH1 and TH2) pathways, defined by cytokines interferon-γ (IFN-γ)
and interleukin-4 (IL-4), respectively, comprise two alternative CD4+ T-cell fates, with …