Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …

Abstract PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is
overexpressed in several human cancers that are associated with poor prognosis. High …

Cardiac ischemia–reperfusion (I/R) injury results mainly from mitochondrial dysfunction and
cardiomyocyte death. Mitophagy sustains mitochondrial function and exerts a pro-survival …

Nuclear factor erythroid-2 related factor-2 (Nrf2) is an oxidative stress-response
transcriptional activator that promotes carcinogenesis through metabolic reprogramming …

A series of novel substituted 2-(4-bromophenyl)-4-phenylthiazole compounds 5a–h were
synthesized by a simplified two-step process. First, the selective and effective α-bromination …

Excessive mitochondrial fission has been identified as the pathogenesis of diabetic
nephropathy (DN), although the upstream regulatory signal for mitochondrial fission …

Mitochondrial damage is involved in the pathogenesis of post-infarction cardiac injury.
However, the upstream regulators of mitochondrial damage have not yet been identified …

Sirtuins (SIRT) are unique posttranslational modification enzymes that utilize NAD+ as co-
substrate to remove acyl groups from lysine residues. SIRT act on variety of substrates and …