The growing genetic and functional diversity of extended spectrum beta‐lactamases

S ur Rahman, T Ali, I Ali, NA Khan… - BioMed research …, 2018 - Wiley Online Library
The β‐lactams—a large class of diverse compounds—due to their excellent safety profile
and broad antimicrobial spectrum are considered to be the most widely used therapeutic …

Extended spectrum beta-lactamases: definition, classification and epidemiology

S Ghafourian, N Sadeghifard, S Soheili… - Current issues in …, 2015 - mdpi.com
Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain
bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore …

[HTML][HTML] Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment

S Shaikh, J Fatima, S Shakil, SMD Rizvi… - Saudi journal of …, 2015 - Elsevier
Antibiotic resistance is a problem of deep scientific concern both in hospital and community
settings. Rapid detection in clinical laboratories is essential for the judicious recognition of …

Prevalence of Multidrug Resistance and Extended‐Spectrum β‐Lactamase Carriage of Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia

A Alqasim, A Abu Jaffal… - International journal of …, 2018 - Wiley Online Library
The prevalence of extended‐spectrum β‐lactamase‐producing Escherichia coli (ESBL‐
producing E. coli) has recently increased worldwide. This study aims at determining the …

β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula

HM Zowawi, HH Balkhy, TR Walsh… - Clinical microbiology …, 2013 - Am Soc Microbiol
Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality
worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation …

Molecular characterization of extended-spectrum beta-lactamase producing Enterobacteriaceae in a Saudi Arabian tertiary hospital

H Hassan, B Abdalhamid - The Journal of Infection in Developing Countries, 2014 - jidc.org
Introduction: The aim of this study was to determine the prevalence of extended-spectrum
beta-lactamase (ESBL) producing Escherichia coli (E. coli), Klebsiella pneumoniae (K …

Emergence of blaTEM, blaCTX‑M, blaSHV and blaOXA genes in multidrug‑resistant Enterobacteriaceae and Acinetobacter baumannii in Saudi Arabia

ME Ibrahim, TB Algak, M Abbas… - Experimental and …, 2021 - spandidos-publications.com
Multidrug‑resistant (MDR) patterns due to extended‑spectrum β‑lactamase (ESBL)
production in pathogenic bacteria are now becoming prevalent in hospitals worldwide …

The occurrence of ESBL-producing Escherichia coli carrying aminoglycoside resistance genes in urinary tract infections in Saudi Arabia

EJ Alyamani, AM Khiyami, RY Booq… - Annals of clinical …, 2017 - Springer
Background The infection and prevalence of extended-spectrum β-lactamases (ESBLs) is a
worldwide problem, and the presence of ESBLs varies between countries. In this study, we …

Whole genome characterization of the high-risk clone ST383 Klebsiella pneumoniae with a simultaneous carriage of bla CTX-M-14 on IncL/M plasmid and bla CTX-M …

EA Edward, NM Mohamed, AS Zakaria - Microorganisms, 2022 - mdpi.com
Recently, Egypt has witnessed the emergence of multidrug-resistant (MDR) Klebsiella
pneumoniae, which has posed a serious healthcare challenge. The accelerated …

Clonal diversity and genetic profiling of antibiotic resistance among multidrug/carbapenem-resistant Klebsiella pneumoniae isolates from a tertiary care hospital in …

T Zaman, M Alrodayyan, M Albladi, M Aldrees… - BMC infectious …, 2018 - Springer
Background The nexus between resistance determinants, plasmid type, and clonality
appears to play a crucial role in the dissemination and survival of carbapenem-resistant …