Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Psychoactive substance use is a nearly universal human behavior, but a significant minority
of people who use addictive substances will go on to develop an addictive disorder …

Substance use continues to contribute to significant morbidity and mortality in the United
States, for both women and men, more so than any other preventable health condition. To …

Objective: Alcohol use disorder (AUD) is a leading cause of global disease burden. Chronic,
heavy use increases the likelihood of alcohol withdrawal symptoms and associated …

Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting~
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …

Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

The central noradrenergic system innervates almost all regions of the brain and, as such, is
well positioned to modulate many neural circuits implicated in behaviors and physiology …