Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F
transcription factor are conserved in many species of plants and animals. The mammalian …

The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is
the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research …

The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has
remained unknown whether not only lesion-type-specific, but overall repair capacities could …

Intestinal epithelial cells are exposed to both innocuous and pathogenic microbes, which
need to be distinguished to mount an effective immune response. To understand the …

Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response
(HSR) and is essential for stress resilience. HSF is also required for metazoan development; …

The development of a multicellular organism and physiological responses require massive
coordinated changes in gene expression across several cell and tissue types,,. Polymorphic …

Parental infection can result in the production of offspring with enhanced immunity
phenotypes. Critically, the mechanisms underlying inherited immunity are poorly …

Previous studies demonstrated that a subset of synMuv B mutants ectopically misexpress
germline-specific P-granule proteins in their somatic cells, suggesting a failure to properly …

During animal development, a single fertilized egg forms a complete organism with tens to
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …

Although now dogma, the idea that nonvertebrate organisms such as yeast, worms, and flies
could inform, and in some cases even revolutionize, our understanding of oncogenesis in …