Mechanosensory hair bundles are assembled from actin-based stereocilia that project from
the apical surface of hair cells in the inner ear. Stereocilia architecture is critical for the …

In the inner ear, the auditory and vestibular systems detect and translate sensory information
regarding sound and balance. The sensory cells that transform mechanical input into an …

Sensory neurons use specialized apical processes to perceive external stimuli and monitor
internal body conditions. The apical apparatus can include cilia, microvilli, or both, and is …

Sensory‐independent Ca2+ spiking regulates the development of mammalian sensory
systems. In the immature cochlea, inner hair cells (IHCs) fire spontaneous Ca2+ action …

Hair cell bundles consist of stereocilia arranged in rows of increasing heights, connected by
tip links that transmit sound-induced forces to shorter stereocilia tips. Auditory …

Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that
transduce sounds and accelerations. Each hair bundle is comprised of∼ 100 individual …

Background Sensorineural hearing loss is one of the most common sensory deficiencies.
However, the molecular contribution to age-related hearing loss is not fully elucidated …

Key points We investigated hair‐cell regeneration in the zebrafish lateral line following the
application of the ototoxic compound copper. In early‐larval zebrafish (< 10 days post …

The mechanoelectrical transduction (MET) protein complex in the inner-ear hair cells is
essential for hearing and balance perception. Calcium and integrin-binding protein 2 (CIB2) …

The hair bundle, or stereocilia bundle, is the mechanosensory compartment of hair cells
(HCs) in the inner ear. To date, most mechanistic studies have focused on stereocilia bundle …