Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Right ventricular (RV) heart failure is the leading cause of death in pulmonary arterial
hypertension (PAH). Peroxisome proliferator–activated receptor γ (PPARγ) acts as a …

The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

In recent years, the vital role of genetic factors in human diseases have been widely
recognized by scholars with the deepening of life science research, accompanied by the …

Rationale: Arterial remodeling—a hallmark of many cardiovascular pathologies including
pulmonary arterial hypertension (PAH)—is regulated by TGFβ1 (transforming growth factor …

Pulmonary arterial hypertension (PAH) is a progressive and devastating disease
characterized by pulmonary artery vasoconstriction and vascular remodeling leading to …

Translational research is essential to the development of reverse-remodeling strategies for
the treatment of pulmonary vascular disease, pulmonary hypertension, and heart failure via …

Recent genome‐wide analyses of rare and common sequence variations have brought
greater clarity to the genetic architecture of pulmonary arterial hypertension and implicated …

Therapeutic options for right ventricular (RV) dysfunction and failure are strongly limited.
Right heart failure (RHF) has been mostly addressed in the context of pulmonary arterial …