[HTML][HTML] Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma
A Barzegar Behrooz, Z Talaie, F Jusheghani… - International journal of …, 2022 - mdpi.com
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
Glioblastoma: current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
[HTML][HTML] Clinical perspective of FDA approved drugs with P-glycoprotein inhibition activities for potential cancer therapeutics
JI Lai, YJ Tseng, MH Chen, CYF Huang… - Frontiers in …, 2020 - frontiersin.org
P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …
[HTML][HTML] Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
[HTML][HTML] Developments in blood-brain barrier penetrance and drug repurposing for improved treatment of glioblastoma
Glioblastoma (GBM) is one of the most common, deadly, and difficult-to-treat adult brain
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …
[HTML][HTML] Thioridazine enhances P62-mediated autophagy and apoptosis through Wnt/β-catenin signaling pathway in glioma cells
CW Chu, HJ Ko, CH Chou, TS Cheng… - International journal of …, 2019 - mdpi.com
Thioridazine (THD) is a common phenothiazine antipsychotic drug reported to suppress
growth in several types of cancer cells. We previously showed that THD acts as an …
growth in several types of cancer cells. We previously showed that THD acts as an …
[HTML][HTML] Overview of cancer stem cells and stemness for community oncologists
Advances in cancer research in the past have led to an evolving understanding of cancer
pathogenesis and the development of novel drugs that significantly improve patient …
pathogenesis and the development of novel drugs that significantly improve patient …
[HTML][HTML] Chemotherapy resistance: Role of mitochondrial and autophagic components
E Bahar, SY Han, JY Kim, H Yoon - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …
[HTML][HTML] Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely
highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial …
highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial …
[HTML][HTML] Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
S Matteoni, P Matarrese, B Ascione… - Journal of Experimental …, 2021 - Springer
Abstract Background Glioblastoma (GBM; grade IV glioma) is characterized by a very short
overall survival time and extremely low 5-year survival rates. We intend to promote …
overall survival time and extremely low 5-year survival rates. We intend to promote …