The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

Pancreatic cancer is currently the third leading cause of cancer death in the United States.
The clinical hallmarks of this disease include abdominal pain that radiates to the back, the …

Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive
decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of …

A paradigm shift is occurring in neuroscience and in general in life sciences converting
biomedical research from a descriptive discipline into a quantitative, predictive, actionable …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types, and their …

Elucidating how synaptic molecules such as AMPA receptors mediate neuronal
communication and tracking their dynamic expression during behavior is crucial to …

Previous research has emphasized the unique impact of Alzheimer's Disease (AD)
pathology on the medial temporal lobe (MTL), a reflection that tau pathology is particularly …

This paper explicates a solution to building correspondences between molecular-scale
transcriptomics and tissue-scale atlases. This problem arises in atlas construction and cross …

Reconstructing dense 3D anatomical coordinates from 2D projective measurements has
become a central problem in digital pathology for both animal models and human studies …