Technologies such as next-generation sequencing and chromosomal microarray have
advanced the understanding of the molecular pathogenesis of a variety of renal disorders …

This international multidisciplinary document intends to provide clinicians with evidence-
based practical patient-centered recommendations for evaluating patients and decedents …

Patient-reported outcome measures (PROMs) are used to facilitate patient-centered care
(PCC). While studies in patients with cardiac conditions have revealed poorer health-related …

Purpose Sudden cardiac death (SCD) in the young is a devastating event occurring in
otherwise healthy individuals. Postmortem genetic testing (molecular autopsy) may help …

Given the dynamic nature of the electrical activity of the heart and ongoing challenges in the
diagnostics of inherited heart rhythm disorders, genetic information can be a vital aspect of …

Background: Increasing use of genetic tests have identified many variants of uncertain
significance (VUS) in genes associated with inherited arrhythmias and cardiomyopathies …

Cardiovascular genetic counseling has expanded as an established genetic counseling
specialty over the last 20 years. Despite guidelines recommending genetic counseling for …

Background The role of multidisciplinary clinics for psychosocial care is increasingly
recognized for those living with inherited cardiac conditions (ICC). In Canada, access to …

Primary hypertension is a multiplex and multifactorial disease influenced by various strong
components including genetics. Extensive research such as Genome-wide association …

To that end, this article presents the existing knowledge enabling a genome-first approach to
ARVC and describes the major challenges. We also present findings for some of the first …