Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

The persistence of neurogenesis in the forebrain subventricular zone (SVZ) of adult
mammals suggests that the mature brain maintains the potential for neuronal replacement …

The present study investigates the induction of neurogenesis, reduction of apoptosis, and
promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by …

Though the vascular system of the adult brain is extremely stable under normal baseline
conditions, endothelial cells start to proliferate in response to brain ischemia. The induction …

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

Cerebral ischemia leads to brain damage caused by pathogenetic mechanisms that are also
activated by neurotrauma. These mechanisms include among others excitotoxicity, over …

Fibroblast growth factor-2 (FGF-2) promotes proliferation of neuroprogenitor cells in culture
and is up-regulated within brain after injury. Using mice genetically deficient in FGF-2 (FGF …

Though the ischemic penumbra has been classically described on the basis of blood flow
and physiologic parameters, a variety of ischemic penumbras can be described in molecular …

The persistence of neurogenesis in the adult mammalian forebrain suggests that
endogenous precursors may be a potential source for neuronal replacement after injury or …