New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN

A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

The sodium leak channel, NALCN, in health and disease

M Cochet-Bissuel, P Lory, A Monteil - Frontiers in cellular …, 2014 - frontiersin.org
Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …

[HTML][HTML] A conserved bicycle model for circadian clock control of membrane excitability

M Flourakis, E Kula-Eversole, AL Hutchison, TH Han… - Cell, 2015 - cell.com
Circadian clocks regulate membrane excitability in master pacemaker neurons to control
daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives …

Structure of the human sodium leak channel NALCN

M Kschonsak, HC Chua, CL Noland, C Weidling… - Nature, 2020 - nature.com
Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability,. The ion
channel responsible for the major background Na+ conductance in neurons is the Na+ leak …

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

W Elkhatib, LA Yanez-Guerra, TD Mayorova… - Communications …, 2023 - nature.com
ASIC channels are bilaterian proton-gated sodium channels belonging to the large and
functionally-diverse Deg/ENaC family that also includes peptide-and mechanically-gated …

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium

HC Chua, M Wulf, C Weidling, LP Rasmussen… - Science …, 2020 - science.org
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain

AN King, A Sehgal - European Journal of Neuroscience, 2020 - Wiley Online Library
A central question in the circadian biology field concerns the mechanisms that translate~ 24‐
hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a …

Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals

DY Romanova, IV Smirnov, MA Nikitin, AB Kohn… - Biochemical and …, 2020 - Elsevier
Placozoa are small disc-shaped animals, representing the simplest known, possibly
ancestral, organization of free-living animals. With only six morphological distinct cell types …

Brain transcriptome changes in the aging Drosophila melanogaster accompany olfactory memory performance deficits

R Pacifico, CM MacMullen, E Walkinshaw, X Zhang… - PloS one, 2018 - journals.plos.org
Cognitive decline is a common occurrence of the natural aging process in animals and
studying age-related changes in gene expression in the brain might shed light on disrupted …

Thigmo responses: the fungal sense of touch

MC Almeida, AC Brand - Microbiology spectrum, 2017 - Am Soc Microbiol
The growth and development of most fungi take place on a two-dimensional surface or
within a three-dimensional matrix. The fungal sense of touch is therefore critical for fungi in …