New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …
action of a large repertoire of membrane proteins, especially ion channels. Unique …
The sodium leak channel, NALCN, in health and disease
M Cochet-Bissuel, P Lory, A Monteil - Frontiers in cellular …, 2014 - frontiersin.org
Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …
[HTML][HTML] A conserved bicycle model for circadian clock control of membrane excitability
Circadian clocks regulate membrane excitability in master pacemaker neurons to control
daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives …
daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives …
Structure of the human sodium leak channel NALCN
Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability,. The ion
channel responsible for the major background Na+ conductance in neurons is the Na+ leak …
channel responsible for the major background Na+ conductance in neurons is the Na+ leak …
Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa
W Elkhatib, LA Yanez-Guerra, TD Mayorova… - Communications …, 2023 - nature.com
ASIC channels are bilaterian proton-gated sodium channels belonging to the large and
functionally-diverse Deg/ENaC family that also includes peptide-and mechanically-gated …
functionally-diverse Deg/ENaC family that also includes peptide-and mechanically-gated …
The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium
HC Chua, M Wulf, C Weidling, LP Rasmussen… - Science …, 2020 - science.org
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …
Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain
AN King, A Sehgal - European Journal of Neuroscience, 2020 - Wiley Online Library
A central question in the circadian biology field concerns the mechanisms that translate~ 24‐
hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a …
hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a …
Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals
Placozoa are small disc-shaped animals, representing the simplest known, possibly
ancestral, organization of free-living animals. With only six morphological distinct cell types …
ancestral, organization of free-living animals. With only six morphological distinct cell types …
Brain transcriptome changes in the aging Drosophila melanogaster accompany olfactory memory performance deficits
R Pacifico, CM MacMullen, E Walkinshaw, X Zhang… - PloS one, 2018 - journals.plos.org
Cognitive decline is a common occurrence of the natural aging process in animals and
studying age-related changes in gene expression in the brain might shed light on disrupted …
studying age-related changes in gene expression in the brain might shed light on disrupted …
Thigmo responses: the fungal sense of touch
MC Almeida, AC Brand - Microbiology spectrum, 2017 - Am Soc Microbiol
The growth and development of most fungi take place on a two-dimensional surface or
within a three-dimensional matrix. The fungal sense of touch is therefore critical for fungi in …
within a three-dimensional matrix. The fungal sense of touch is therefore critical for fungi in …