Cancer therapy has entered a new era, transitioning from unspecific chemotherapeutic
agents to increasingly specific immune-based therapeutic strategies. Among these, chimeric …

The concept of gene therapy originated in the mid twentieth century and was perceived as a
revolutionary technology with the promise to cure almost any disease of which the molecular …

γ-Retroviral vectors (γRVs), which are commonly used in gene therapy, can trigger
oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector …

Insertional mutagenesis represents a major hurdle to gene therapy and necessitates
sensitive preclinical genotoxicity assays. Cdkn2a−/− mice are susceptible to a broad range …

Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo
gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases …

Increasing evidence reveals that random insertion of gene transfer vectors into the genome
of repopulating hematopoietic cells may alter their fate in vivo. Although most insertional …

Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can
produce long-term expression of transgenes in vivo. Although AAV vector genomes can …

Retroviral vectors are often used to introduce therapeutic sequences into patients' cells. In
recent years, gene therapy with retroviral vectors has had impressive therapeutic successes …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

Retroviral vectors with long terminal repeats (LTRs), which contain strong
enhancer/promoter sequences at both ends of their genome, are widely used for stable …