Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
The growth hormone signaling system: Insights into coordinating the anabolic and catabolic actions of growth hormone
HE Bergan-Roller, MA Sheridan - General and comparative endocrinology, 2018 - Elsevier
Although growth hormone (GH) is a multifunctional factor that coordinates various aspects of
feeding, reproduction, osmoregulation, and immune system function, perhaps two of its most …
feeding, reproduction, osmoregulation, and immune system function, perhaps two of its most …
Multiple effects of growth hormone in the body: is it really the hormone for growth?
J Devesa, C Almengló… - Clinical Medicine Insights …, 2016 - journals.sagepub.com
In this review, we analyze the effects of growth hormone on a number of tissues and organs
and its putative role in the longitudinal growth of an organism. We conclude that the …
and its putative role in the longitudinal growth of an organism. We conclude that the …
The impact of adipose tissue on insulin resistance in acromegaly
NC Olarescu, J Bollerslev - Trends in Endocrinology & Metabolism, 2016 - cell.com
Adipose tissue (AT) is recognized as key contributor to the systemic insulin resistance and
overt diabetes seen in metabolic syndrome. Acromegaly is a disease characterized by …
overt diabetes seen in metabolic syndrome. Acromegaly is a disease characterized by …
Acute sprint exercise transcriptome in human skeletal muscle
HC Rundqvist, A Montelius, T Osterlund, B Norman… - PLoS …, 2019 - journals.plos.org
Aim To examine global gene expression response to profound metabolic and hormonal
stress induced by acute sprint exercise. Methods Healthy men and women (n= 14) …
stress induced by acute sprint exercise. Methods Healthy men and women (n= 14) …
Growth hormone and obesity
A Hjelholt, M Høgild, AM Bak… - Endocrinology and …, 2020 - endo.theclinics.com
Growth hormone (GH) is a peptide hormone secreted from the pituitary gland with pleiotropic
metabolic effects. 1, 2 It is essential for induction of postnatal longitudinal growth and this …
metabolic effects. 1, 2 It is essential for induction of postnatal longitudinal growth and this …
The acromegaly lipodystrophy
PU Freda - Frontiers in endocrinology, 2022 - frontiersin.org
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are essential to normal growth,
metabolism, and body composition, but in acromegaly, excesses of these hormones …
metabolism, and body composition, but in acromegaly, excesses of these hormones …
Gene expression signature in adipose tissue of acromegaly patients
To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA
sequencing in adipose tissue biopsies from patients with acromegaly (n= 7) or non …
sequencing in adipose tissue biopsies from patients with acromegaly (n= 7) or non …
The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals
Aim Since GH stimulates lipolysis in vivo after a 2‐hr lag phase, we studied whether this
involves GH signaling and gene expression in adipose tissue (AT). Methods Human …
involves GH signaling and gene expression in adipose tissue (AT). Methods Human …
Loss of adipocyte Stat5 confers increased depot-specific adiposity in Male and female mice that is not associated with altered adipose tissue lipolysis
AJ Richard, H Hang, TD Allerton, P Zhao… - Frontiers in …, 2022 - frontiersin.org
STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during
adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin …
adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin …