Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

Osteoporosis is defined as a skeletal disorder of compromised bone strength predisposing
those affected to an elevated risk of fracture. However, based on bone histology …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

The first clinical trial of an implantable microchip-based drug delivery device is discussed.
Human parathyroid hormone fragment (1–34)[hPTH (1–34)] was delivered from the device …

Intermittent administration of parathyroid hormone (PTH) stimulates bone formation by
increasing osteoblast number, but the molecular and cellular mechanisms underlying this …

Intermittent parathyroid hormone (PTH) application is an established pharmacological
principle to stimulate bone formation. Yet, the molecular mechanisms underlying this bone …

One of the well characterized cell biologic actions of lithium is the inhibition of glycogen
synthase kinase-3β and the consequent activation of canonical Wnt signaling. Because …