Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications
Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …
determinants, but also controlled by endogenous and environmental cues. Substantial …
The impact of childhood cancer and its treatment on puberty and subsequent hypothalamic pituitary and gonadal function, in both boys and girls
C Wei, E Crowne - Best practice & research Clinical endocrinology & …, 2019 - Elsevier
Childhood cancer survivors (CCS) are at an increased risk of endocrine disorders. Disorders
of the hypothalamic-pituitary-gonadal (HPG) axis are a particular concern because of their …
of the hypothalamic-pituitary-gonadal (HPG) axis are a particular concern because of their …
Central precocious puberty in italian boys: data from a large nationwide cohort
A Cassio, G Marescotti, T Aversa… - The Journal of …, 2024 - academic.oup.com
Context There are only a few nationwide studies on boys with central precocious puberty
(CPP) and the last Italian study is a case series of 45 boys that dates back to 2000. Objective …
(CPP) and the last Italian study is a case series of 45 boys that dates back to 2000. Objective …
[HTML][HTML] Precocious puberty or premature thelarche: analysis of a large patient series in a single tertiary center with special emphasis on 6-to 8-year-old girls
T Varimo, H Huttunen, PJ Miettinen, L Kariola… - Frontiers in …, 2017 - frontiersin.org
Introduction We describe the etiology, MRI findings, and growth patterns in girls who had
presented with signs of precocious puberty (PP), ie, premature breast development or early …
presented with signs of precocious puberty (PP), ie, premature breast development or early …
Central precocious puberty as a presenting sign of nonclassical congenital adrenal hyperplasia: clinical characteristics
B Neeman, R Bello, L Lazar, M Phillip… - The Journal of Clinical …, 2019 - academic.oup.com
Context Central precocious puberty (CPP) may be the first presentation of nonclassical
congenital adrenal hyperplasia (NCCAH) in girls. Data on the prevalence and the clinical …
congenital adrenal hyperplasia (NCCAH) in girls. Data on the prevalence and the clinical …
Evaluation and treatment results of ovarian cysts in childhood and adolescence: a multicenter, retrospective study of 100 patients
Abstract Study Objective To investigate the characteristics of children with ovarian cysts and
evaluate treatment strategies. Design Retrospective study. Setting Eight pediatric …
evaluate treatment strategies. Design Retrospective study. Setting Eight pediatric …
The follicle-stimulating hormone (FSH) and luteinizing hormone (LH) response to a gonadotropin-releasing hormone analogue test in healthy prepubertal girls aged …
ET Vestergaard, ME Schjørring… - European Journal of …, 2017 - academic.oup.com
Objective Premature thelarche and precocious puberty are frequently diagnosed in girls
even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH …
even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH …
Vaginal bleeding in children: A retrospective audit at a tertiary paediatric gynaecology service
N Drever, S Peek, D Moussaoui… - … of Paediatrics and …, 2023 - Wiley Online Library
Aim The aim of this study was to describe the clinical features and investigations of vaginal
bleeding in prepubertal children. Methods We performed a retrospective case series of …
bleeding in prepubertal children. Methods We performed a retrospective case series of …
[PDF][PDF] Definition, etiology, and evaluation of precocious puberty
J Harrington, MR Palmert - Up To Date, Section Editors: Peter J. Snyder …, 2022 - obgin.net
Precocious puberty is the onset of pubertal development at an age that is 2 to 2.5 standard
deviations (SD) earlier than population norms. The cause of precocious puberty may range …
deviations (SD) earlier than population norms. The cause of precocious puberty may range …
[HTML][HTML] Peripheral precocious puberty of ovarian origin in a series of 18 girls: Exome study finds variants in genes responsible for hypogonadotropic hypogonadism
R Brauner, J Bignon-Topalovic, A Bashamboo… - Frontiers in …, 2021 - frontiersin.org
Background: Peripheral precocious puberty of ovarian origin is a very rare condition
compared to central form. It may be associated with an isolated ovarian cyst (OC). The …
compared to central form. It may be associated with an isolated ovarian cyst (OC). The …