Cyclophosphamide remains one of the most successful and widely utilized antineoplastic
drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used …

The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been
used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and …

Cyclophosphamide (Cy) is a potent immunosuppressive agent that is selectively toxic to
lymphocytes proliferating in response to recent antigen stimulation. In animal models, both …

Abstract Objective CD40–CD40 ligand (CD40L) interactions play a significant role in the
production of autoantibodies and tissue injury in lupus nephritis. We performed an open …

Background: Controlled trials in lupus nephritis have demonstrated that cyclophosphamide
therapy is superior to corticosteroid therapy alone. The long-term effectiveness and side …

Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by
autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct …

Evans syndrome is an uncommon condition defined by the combination (either
simultaneously or sequentially) of immune thrombocytopenia (ITP) and autoimmune …

In this overview of the pharmacology of the anticancer drug cyclophosphamide, a brief
history of the development of this drug from the general class of nitrogen mustards is …

Cyclophosphamide's lack of hematopoietic stem cell toxicity and its unique effects on the
immune system have prompted several investigators to explore its potential for the …

Background Patients with systemic lupus erythematosus (SLE) who experience persistent
multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide, represent …