The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Correlation and association analyses are one of the most widely used statistical methods in
research fields, including microbiome and integrative multiomics studies. Correlation and …

Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological …

The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …

RNA sequencing (RNA-seq) is one of the most widely used technologies in transcriptomics
as it can reveal the relationship between the genetic alteration and complex biological …

The nervous and immune systems are intricately linked. Although psychological stress is
known to modulate immune function, mechanistic pathways linking stress networks in the …

Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure
is the major cause of recurrence and poor prognosis in colorectal cancer patients. Here, we …

An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …

Background Data from 16S ribosomal RNA (rRNA) amplicon sequencing present
challenges to ecological and statistical interpretation. In particular, library sizes often vary …

Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor
(IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for …