Investigating underlying molecular mechanisms, signaling pathways, emerging therapeutic approaches in pancreatic cancer
Pancreatic adenocarcinoma, a clinically challenging malignancy constitutes a significant
contributor to cancer-related mortality, characterized by an inherently poor prognosis. This …
contributor to cancer-related mortality, characterized by an inherently poor prognosis. This …
[HTML][HTML] CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression
and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative …
and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative …
Personalized treatment using predictive biomarkers in solid organ malignancies: A review
H Tang, YX Li, JJ Lian, HY Ng, SSY Wang - Tumori Journal, 2024 - journals.sagepub.com
In recent years, the influence of specific biomarkers in the diagnosis and prognosis of solid
organ malignancies has been increasingly prominent. The relevance of the use of predictive …
organ malignancies has been increasingly prominent. The relevance of the use of predictive …
[HTML][HTML] Microbubble-Protected Oncolytic Virotherapy Targeted by Sonoporation Induces Tumor Necrosis and T-Lymphocyte Infiltration in Humanized Mice Bearing …
J Sitta, F De Carlo, I Kirven, JH Tackett… - International Journal of …, 2024 - mdpi.com
Oncolytic virotherapy has shown great promise in mediating targeted tumor destruction
through tumor-selective replication and induction of anti-tumor immunity; however, obstacles …
through tumor-selective replication and induction of anti-tumor immunity; however, obstacles …
[HTML][HTML] Early-Stage Luminal B-Like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-Like Breast Cancer
T Moura, O Caramelo, I Silva, S Silva, M Gonçalo… - Biomolecules, 2025 - mdpi.com
Background: Breast cancer is a heterogeneous malignant disease with a varying prognosis
and is classified into four molecular subtypes. It remains one of the most prevalent cancers …
and is classified into four molecular subtypes. It remains one of the most prevalent cancers …
[HTML][HTML] Prognostic impact of tumor-associated neutrophils in breast cancer
A Kakumoto, T Jamiyan, H Kuroda… - … Journal of Clinical …, 2024 - ncbi.nlm.nih.gov
Objectives: Neutrophils are the most common type of leukocyte in mammals and play an
essential role in the innate immune system and anti-cancer responses. However, recent …
essential role in the innate immune system and anti-cancer responses. However, recent …
[HTML][HTML] CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression
and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative …
and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative …
[HTML][HTML] Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER− breast …
Multiple immunosuppressive mechanisms exist in the tumor microenvironment that drive
poor outcomes and decrease treatment efficacy. The co-expression of NOS2 and COX2 is a …
poor outcomes and decrease treatment efficacy. The co-expression of NOS2 and COX2 is a …
Integrated multiomics analysis unveils how macrophages drive immune suppression in breast tumors and affect clinical outcomes
Despite thorough characterizations of cellular compositions within the breast tumor
microenvironment (TME), their implications for disease progression and patient prognosis …
microenvironment (TME), their implications for disease progression and patient prognosis …
[HTML][HTML] Immune modulation and epigenetic therapies for enhanced outcome of treatment in triple-negative breast cancer
VC Okwor, CJ Okwor, SA Musayayi… - Tumor …, 2024 - accscience.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the
absence of human epidermal growth factor receptor 2, estrogen receptor, and progesterone …
absence of human epidermal growth factor receptor 2, estrogen receptor, and progesterone …