SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now
generally accepted to be the major players in the final stage of the docking and the …

The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The
intracellular parasite can persist lifelong in the CNS within neurons modifying their function …

Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased
levels of functional synaptic proteins as found in autopsied brains of patients with …

The maintenance of synaptic transmission requires that vesicles be recycled after releasing
neurotransmitter. Several modes of retrieval have been proposed to operate at small …

Exposure to environmental enrichment can beneficially influence the behavior and enhance
synaptic plasticity. The aim of the present study was to investigate the mediated effects of …

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well
established that rodents exposed to diets rich in saturated fat develop brain dysfunction …

Neuroinflammation plays a critical role in the progression of many neurodegenerative,
neuropsychiatric and viral diseases. In neuroinflammation, activated microglia and …

Amyloid-β (Aβ) peptides play a key role in the pathogenesis of Alzheimer's disease and
exert various toxic effects on neurons; however, relatively little is known about their influence …

Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the
central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide …

The integral membrane protein synaptophysin is one of the most abundant polypeptide
components of synaptic vesicles. It is not essential for neurotransmission despite its …