The S100 proteins comprise at least 25 members, forming the largest group of EF-hand
signalling proteins in humans. Although the proteins are expressed in many tissues, each …

The calcium binding proteins of the EF-hand super-family are involved in the regulation of all
aspects of cell function. These proteins exhibit a great diversity of composition, structure …

A tunable, weak degree of macromolecular alignment with respect to a static magnetic field
can be obtained in a dilute, lyotropic liquid crystalline phase. 1 Provided the degree of solute …

The transition from benign tumor growth to malignancy is manifested by the ability of tumor
cells to traverse tissue barriers and invade surrounding tissues. The traversal of basement …

Structure determination by nuclear magnetic resource (NMR) traditionally has relied on the
measurement of a maximum possible number of semiquantitative local restraints. The most …

Protein solution nuclear magnetic resonance (NMR) can be conducted in a slightly
anisotropic environment, where the orientational distribution of the proteins is no longer …

A Ca 2+ dependent conformational change in dimeric S100B (ββ) is required for it to bind
p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative …

This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …

The EF‐hand motif, which assumes a helix‐loop‐helix structure normally responsible for
Ca2+ binding, is found in a large number of functionally diverse Ca2+ binding proteins …

Nervous system development and plasticity require regulation of cell proliferation, survival,
neurite outgrowth and synapse formation by specific extracellular factors. The EF‐hand …