Companion animals in comparative oncology: One Medicine in action
OA Garden, SW Volk, NJ Mason, JA Perry - The Veterinary Journal, 2018 - Elsevier
Comparative oncology is poised to have a far-reaching impact on both animals and human
beings with cancer. The field is gaining momentum and has repeatedly proven its utility in …
beings with cancer. The field is gaining momentum and has repeatedly proven its utility in …
Translational pain assessment: could natural animal models be the missing link?
Failure of analgesic drugs in clinical development is common. Along with the current
“reproducibility crisis” in pain research, this has led some to question the use of animal …
“reproducibility crisis” in pain research, this has led some to question the use of animal …
The UCSC genome browser database: 2015 update
Launched in 2001 to showcase the draft human genome assembly, the UCSC Genome
Browser database (http://genome. ucsc. edu) and associated tools continue to grow …
Browser database (http://genome. ucsc. edu) and associated tools continue to grow …
FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify …
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify …
Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture
Abstract Background The international Dog10K project aims to sequence and analyze
several thousand canine genomes. Incorporating 20× data from 1987 individuals, including …
several thousand canine genomes. Incorporating 20× data from 1987 individuals, including …
Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2
Abstract The recent pandemic, COVID-19, is caused by a novel coronavirus, SARS-CoV-2,
with elusive origin. SARS-CoV-2 infects mammalian cells via ACE2, a transmembrane …
with elusive origin. SARS-CoV-2 infects mammalian cells via ACE2, a transmembrane …
[HTML][HTML] Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas
Original research: Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and
TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas - PMC Back …
TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas - PMC Back …
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics
L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey… - Scientific Reports, 2023 - nature.com
Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …
To better understand these similarities, we investigated 671 client-owned dogs from 96 …
FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs
EA Brown, PJ Dickinson, T Mansour… - Proceedings of the …, 2017 - National Acad Sciences
Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature
degeneration and calcification of intervertebral discs. Independent genome-wide …
degeneration and calcification of intervertebral discs. Independent genome-wide …
[HTML][HTML] Jagged 1 rescues the Duchenne muscular dystrophy phenotype
Duchenne muscular dystrophy (DMD), caused by mutations at the dystrophin gene, is the
most common form of muscular dystrophy. There is no cure for DMD and current therapeutic …
most common form of muscular dystrophy. There is no cure for DMD and current therapeutic …