Lipopolysaccharides (LPSs) are bacterial surface glycolipids, produced by Gram-negative
bacteria. LPS is known to determine acute inflammatory reactions, particularly in the context …

Inflammatory bowel disease is a progressive and debilitating condition. Early and effective
treatment utilizing a treat to target approach is key in improving patient outcomes. Therefore …

Background & Aims Biomarkers are used frequently for noninvasive monitoring and
treatment decision making in the management of patients with ulcerative colitis (UC). This …

Introduction Although there are well-defined guidelines for the management of mild-to-
moderate ulcerative colitis (UC), there are still unmet needs. For this reason, we conducted …

Breaking through the biologic therapy efficacy plateau for inflammatory bowel disease
requires the strategic development of personalized biomarkers in the tight control model …

Background & Aims Colonoscopy (CS) is the gold standard to assess postoperative
recurrence (POR) in Crohn's disease (CD). However, CS is invasive and may be poorly …

Managing inflammatory bowel disease (IBD) is becoming increasingly complex and
personalized, considering the advent of new advanced therapies with distinct mechanisms …

Background Inflammatory bowel disease (IBD) comprises a group of chronic conditions
characterized by relapsing and remitting inflammation of the gastrointestinal tract. The …

Background: While mucosal healing (MH) and transmural healing (TH) predict relevant
clinical outcomes in Crohn's disease (CD), little is known about the real significance and …

Background & Aims Unaffected first-degree relatives (FDRs) from families with≥ 2 affected
FDRs with Crohn's disease (CD, multiplex families) have a high risk of developing CD …