Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and
proliferation leading to the degeneration of cellular structure and function, has been …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here
we demonstrate that the known synthetic lethal interaction between poly (ADP-ribose) …

Quercetin is a flavonoid present in many vegetables, fruits, and beverages. Due to its anti‐
oxidant, anti‐tumor, and anti‐inflammatory activity, quercetin has been studied extensively …

Anastomotic leak (AL) constitutes a significant issue in colorectal surgery, and its incidence
has remained stable over the last years. The use of intra-abdominal drain or the use of …

Treatment of malignancies with chemotherapeutic drugs and/or radiotherapy is designed to
eliminate the disease by depriving the tumor cell of its reproductive potential. Frequently, the …

Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature
senescence under sublethal oxidative stress, however underlying mechanism remains …