The transcription factor p63 is a master regulator of multiple ectodermal derivatives. During
epidermal commitment, p63 interacts with several chromatin remodeling complexes to …

Simple Summary The protein p63 belongs to the family of the p53 tumor suppressor. Mouse
models have, however, shown that it is not a classical tumor suppressor but instead involved …

Epithelial tissues rely on a highly coordinated balance between self-renewal, proliferation,
and differentiation, disruption of which may drive carcinogenesis. The epigenetic regulator …

Secondary palatogenesis occurs when the bilateral palatal shelves (PS), arising from
maxillary prominences, fuse at the midline, forming the hard and soft palate. This embryonic …

Gene expression is controlled by transcription factors (TFs) that bind cognate DNA motif
sequences in cis-regulatory elements (CREs). The combinations of DNA motifs acting within …

ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of
tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene …

The p63 transcription factor is critical for epidermis formation in embryonic development, but
its role in the adult epidermis is poorly understood. In this study, we show that acute genetic …

The ability of cells to adhere to and communicate with other cells and with the extracellular
environment is crucial for morphogenesis and the maintenance of tissue integrity. A cell can …

The p53 family member p63 is a master regulator of gene expression in stratified epithelia,
such as the epidermis. One of the main functions of p63 is to sustain mechanical resistance …

Mutations in transcription factor p63 are associated with developmental disorders that
manifest defects in stratified epithelia including the epidermis. The underlying cellular and …