State-dependent and reflex drives to the upper airway: basic physiology with clinical implications

RL Horner, SW Hughes… - Journal of applied …, 2014 - journals.physiology.org
The root cause of the most common and serious of the sleep disorders is impairment of
breathing, and a number of factors predispose a particular individual to hypoventilation …

Activation of XII motoneurons and premotor neurons during various oropharyngeal behaviors

C Gestreau, M Dutschmann, S Obled… - Respiratory physiology & …, 2005 - Elsevier
Neural control of tongue muscles plays a crucial role in a broad range of oropharyngeal
behaviors. Tongue movements must be rapidly and accurately adjusted in response to the …

Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo

M Hajiha, MA DuBord, H Liu… - The Journal of …, 2009 - Wiley Online Library
Opioids can modulate breathing and predispose to respiratory depression by actions at
various central nervous system sites, but the mechanisms operating at respiratory motor …

Role of endogenous serotonin in modulating genioglossus muscle activity in awake and sleeping rats

S Sood, JL Morrison, H Liu… - American journal of …, 2005 - atsjournals.org
Rationale: Exogenous serotonin at the hypoglossal motor nucleus (HMN) stimulates
genioglossus (GG) muscle activity. However, whether endogenous serotonin contributes to …

Distribution and medullary projection of respiratory neurons in the dorsolateral pons of the rat

K Ezure, I Tanaka - Neuroscience, 2006 - Elsevier
The dorsolateral pons around the parabrachial nucleus including the Kölliker-Fuse nucleus
is closely linked with the medullary respiratory center and plays an important role in …

The brainstem respiratory network: an overview of a half century of research

AL Bianchi, C Gestreau - Respiratory physiology & neurobiology, 2009 - Elsevier
This review aims at summarizing the work performed over 40 years by Professor Armand
Bianchi and the research team he directed, which was devoted to the study of the central …

Neuromodulation of hypoglossal motoneurons during sleep

RL Horner - Respiratory physiology & neurobiology, 2008 - Elsevier
Hypoglossal motoneurons are influenced by a variety of neuromodulators, some of which
change dynamically across sleep–wake states to alter motoneuron excitability and …

Projection neurons of the vestibulo‐sympathetic reflex pathway

GR Holstein, VL Friedrich Jr… - Journal of Comparative …, 2014 - Wiley Online Library
Abstract Changes in head position and posture are detected by the vestibular system and
are normally followed by rapid modifications in blood pressure. These compensatory …

Inhibition of the pontine Kölliker-Fuse nucleus abolishes eupneic inspiratory hypoglossal motor discharge in rat

TG Bautista, M Dutschmann - Neuroscience, 2014 - Elsevier
The pontine Kölliker-Fuse nucleus (KF) has established functions in the regulation of
inspiratory–expiratory phase transition and the regulation of upper airway patency via …

Neural control of the upper airway: integrative physiological mechanisms and relevance for sleep disordered breathing

RL Horner - Comprehensive Physiology, 2011 - Wiley Online Library
The various neural mechanisms affecting the control of the upper airway muscles are
discussed in this review, with particular emphasis on structure‐function relationships and …