Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression

GA Stamatiades, UB Kaiser - Molecular and cellular endocrinology, 2018 - Elsevier
The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

Polypharmacology: drug discovery for the future

AS Reddy, S Zhang - Expert review of clinical pharmacology, 2013 - Taylor & Francis
In recent years, even with remarkable scientific advancements and a significant increase of
global research and development spending, drugs are frequently withdrawn from markets …

The IUPHAR/BPS guide to PHARMACOLOGY in 2024

SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

SD Harding, JF Armstrong, E Faccenda… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.
guidetopharmacology. org) is an open-access, expert-curated database of molecular …

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

SD Harding, JL Sharman, E Faccenda… - Nucleic acids …, 2018 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.
guidetopharmacology. org) and its precursor IUPHAR-DB, have captured expert-curated …

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA …

JF Armstrong, E Faccenda, SD Harding… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

ChEMBL: a large-scale bioactivity database for drug discovery

A Gaulton, LJ Bellis, AP Bento, J Chambers… - Nucleic acids …, 2012 - academic.oup.com
Abstract ChEMBL is an Open Data database containing binding, functional and ADMET
information for a large number of drug-like bioactive compounds. These data are manually …

[HTML][HTML] Open Babel: An open chemical toolbox

NM O'Boyle, M Banck, CA James, C Morley… - Journal of …, 2011 - Springer
Background A frequent problem in computational modeling is the interconversion of
chemical structures between different formats. While standard interchange formats exist (for …

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

AJ Pawson, JL Sharman, HE Benson… - Nucleic acids …, 2014 - academic.oup.com
Abstract The International Union of Basic and Clinical Pharmacology/British
Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www …

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1

AJ Harmar, J Fahrenkrug, I Gozes… - British journal of …, 2012 - Wiley Online Library
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …