[HTML][HTML] Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

RA Marrie, JD Fisk, K Fitzgerald, K Kowalec… - Frontiers in …, 2023 - frontiersin.org
Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based
studies indicate that people with MS have an increased incidence of ischemic heart disease …

[HTML][HTML] Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration

I Stolzer, E Scherer, P Süß, V Rothhammer… - International Journal of …, 2023 - mdpi.com
The gut microbiome plays a pivotal role in maintaining human health, with numerous studies
demonstrating that alterations in microbial compositions can significantly affect the …

[HTML][HTML] Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study

G Cui, S Li, H Ye, Y Yang, Q Huang, Y Chu… - Frontiers in …, 2022 - frontiersin.org
Background Several studies have shown that neurodegenerative diseases (eg, Parkinson's
disease [PD] and Alzheimer's disease [AD]) are associated with inflammatory bowel disease …

Multiple sclerosis and inflammatory bowel disease: A systematic review and meta‐analysis

X Wang, J Wan, M Wang, Y Zhang… - Annals of Clinical and …, 2022 - Wiley Online Library
Background Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are two
autoimmune diseases that seriously affect patients' quality of life. Previous studies have …

Genetic correlation, causal relationship, and shared loci between vitamin D and COVID‐19: A genome‐wide cross‐trait analysis

S Qiu, K Zheng, Y Hu, G Liu - Journal of Medical Virology, 2023 - Wiley Online Library
Observational studies have shown that vitamin D supplementation reduces the risk of
COVID‐19 infection, yet little is known about the shared genomic architectures between …

A systematic review of Mendelian randomization studies on multiple sclerosis

T Fazia, GN Baldrighi, A Nova… - European Journal of …, 2023 - Wiley Online Library
Mendelian randomization (MR) is a powerful approach for assessing the causal effect of
putative risk factors on an outcome, using genetic variants as instrumental variables. The …

Lack of causal associations of inflammatory bowel disease with Parkinson's disease and other neurodegenerative disorders

R Zeng, J Wang, C Zheng, R Jiang, S Tong… - Movement …, 2023 - Wiley Online Library
Background Observational studies have indicated associations between inflammatory bowel
disease (IBD) and neurodegenerative diseases, including Parkinson's disease (PD) …

[HTML][HTML] Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait …

YP Wen, ZG Yu - Frontiers in immunology, 2023 - frontiersin.org
Introduction Substantial links between autoimmune diseases have been shown by an
increasing number of studies, and one hypothesis for this comorbidity is that there is a …

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities

A Afrasiabi, C Ahlenstiel… - Clinical & …, 2023 - Wiley Online Library
Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised
by the demyelination of neurons in the central nervous system. Whilst it is unclear what …

[HTML][HTML] Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis

SK Yadav, N Ito, JE Mindur, H Kumar… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) has been reported to be associated with intestinal inflammation and
gut dysbiosis. To elucidate the underlying biology of MS-linked gut inflammation, we …